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\/>\u90b5\u5706\u901a\u8fc7\u5bf9\u968f\u673a\u62bd\u53d6\u7684\u4ea7\u540e\u5973\u6027\u60a3\u8005\u7ed9\u4e88\u7518\u9ea6\u5927\u67a3\u6c64\u6cbb\u7597 2 \u5468\u540e\uff0c\u53d1\u73b0\u7518\u9ea6\u5927\u67a3\u6c64\u52a0\u51cf\u53ef\u6709\u6548\u6539\u5584\u4ea7\u540e\u5973\u6027\u7761\u7720\u969c\u788d\uff0c\u4e14\u7ea0\u6b63\u4e86\u6291\u90c1\u72b6\u6001\uff0c\u7597\u6548\u503c\u5f97\u80af\u5b9a\u3002\u5218\u5a9b\u3001\u674e\u5148\u6653\u7b49\u901a\u8fc7\u4e34\u5e8a\u89c2\u5bdf\u53d1\u73b0\uff0c\u5e94\u7528\u4e8c\u4ed9\u6c64\u5408\u7518\u9ea6\u5927\u67a3\u6c64\u3001\u7518\u9ea6\u5927\u67a3\u6c64\u5408\u9178\u67a3\u4ec1\u6c64\u52a0\u51cf\u53ef\u6709\u6548\u6539\u5584\u66f4\u5e74\u671f\u5931\u7720\u60a3\u8005\u7684\u7761\u7720\u8d28\u91cf\uff0c\u4e14\u4e34\u5e8a\u6548\u679c\u786e\u5207\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ca9d9a elementor-widget elementor-widget-text-editor\" data-id=\"3ca9d9a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>02.\u98df\u836f\u8d44\u6e90\u6539\u5584\u7761\u7720\u7684\u529f\u80fd\u673a\u5236<\/p><div>\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9dbb746 elementor-widget elementor-widget-text-editor\" data-id=\"9dbb746\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u4f20\u7edf\u4e2d\u533b\u836f\u8c03\u7406\u7761\u7720\u969c\u788d\u7684\u7ecf\u9a8c\u6e90\u4e8e\u4eba\u7c7b\u957f\u671f\u5b9e\u8df5\u548c\u89c2\u5bdf\u7684\u7ed3\u679c\uff0c\u76f8\u5173\u98df\u836f\u8d44\u6e90\u7684\u529f\u80fd\u53ca\u4f5c\u7528\u673a\u5236\u9010\u6b65\u5728\u73b0\u4ee3\u5b9e\u9a8c\u7814\u7a76\u4e2d\u5f97\u5230\u9a8c\u8bc1\u3002<\/p><p>\u7efc\u5408\u6587\u732e\u5206\u6790\u8ba4\u4e3a<strong>\uff0c\u5929\u7136\u98df\u836f\u8d44\u6e90\u6539\u5584\u7761\u7720\u4e3b\u8981\u6d89\u53ca\u795e\u7ecf\u9012\u8d28\u8c03\u8282\u3001\u514d\u75ab\u8c03\u8282\u53ca\u80a0\u9053\u83cc\u7fa4\u8c03\u6574\u7b49\u4f5c\u7528\u673a\u5236\u3002<\/strong><\/p><p><strong>\u2022 \u795e\u7ecf\u9012\u8d28\u8c03\u8282\u4f5c\u7528<\/strong><br \/><strong>\u03b3-\u00a0 \u6c28\u57fa\u4e01\u9178(\u03b3-aminobutyric acid, GABA)<\/strong><br \/>GABA \u00a0\u662f\u4e00\u79cd\u5e7f\u6cdb\u5206\u5e03\u4e8e\u810a\u690e\u52a8\u7269\u3001\u690d\u7269\u548c\u5fae\u751f\u7269\u4e2d\u7684\u975e\u86cb\u767d\u6c28\u57fa\u9178\uff0c\u5c5e\u5f3a\u795e\u7ecf\u6291\u5236\u6027\u6c28\u57fa\u9178\uff0c\u5177\u6709\u9547\u9759\u3001\u50ac\u7720\u3001\u6297\u60ca\u53a5\u3001\u964d\u8840\u538b\u7684\u751f\u7406\u4f5c\u7528\u3002\u738b\u4e3d\u73b2\u7b49\u7814\u7a76\u53d1\u73b0\u7ea2\u67a3\u6539\u5584\u7761\u7720\u4f5c\u7528\u4e0e\u5176\u5bcc\u542b GABA \u6d3b\u6027\u6210\u5206\u6709\u5173\u3002GABA\u53d7\u4f53\u662f\u4e00\u4e2a Cl\uff0d\u901a\u9053\uff0c\u5176\u88ab\u6fc0\u6d3b\u5c06\u5bfc\u81f4 Cl\uff0d\u901a\u9053\u5f00\u653e\uff0c\u589e\u52a0\u7ec6\u80de\u819c\u5bf9 Cl\uff0d\u7684\u901a\u900f\u6027\uff0c\u4f7f Cl\uff0d\u6d41\u5165\u795e\u7ecf\u7ec6\u80de\u5185\u5f15\u8d77\u7ec6\u80de\u819c\u8d85\u6781\u5316\uff0c\u6291\u5236\u795e\u7ecf\u5143\u7ec6\u80de\u7684\u6fc0\u52a8\uff0c\u4ece\u800c\u8fbe\u5230\u9547\u9759\u50ac\u7720\u6548\u679c\u3002GABAA \u53d7\u4f53\u53c8\u79f0\u03b3-\u6c28\u57fa\u4e01\u9178 A \u578b\u53d7\u4f53\uff0c\u5176\u5185\u6e90\u6027\u914d\u4f53\u4e3a GABA\u3002Shah \u7b49\u7814\u7a76\u53d1\u73b0\u832f\u82d3\u9178\u53ef\u5347\u9ad8\u5927\u9f20\u4e0b\u4e18\u8111\u539f\u4ee3\u57f9\u517b\u795e\u7ecf\u5143\u7ec6\u80de\u5185\u7684 Cl\uff0d\u6c34\u5e73\uff0c\u589e\u52a0 GABAA \u53d7\u4f53\u03b1-\u548c\u03b2-\u4e9a\u57fa\u86cb\u767d\u6c34\u5e73\uff0c\u4ece\u800c\u589e\u5f3a\u620a\u5df4\u6bd4\u59a5\u8bf1\u5bfc\u5927\u9f20\u7684\u50ac\u7720\u4f5c\u7528\u3002Nam \u7b49\u7814\u7a76\u53d1\u73b0\u9f99\u773c\u7532\u9187\u63d0\u53d6\u7269\u589e\u5f3a\u4e86\u620a\u5df4\u6bd4\u59a5\u6cbb\u7597\u5c0f\u9f20\u7684\u50ac\u7720\u4f5c\u7528\uff0c\u5176\u4f5c\u7528\u673a\u5236\u4e3a\u901a\u8fc7\u76f4\u63a5\u6fc0\u6d3b GABAA \u53d7\u4f53\u6216\u589e\u52a0 GABAA \u53d7\u4f53\u4e9a\u5355\u4f4d\u8868\u8fbe\uff0c\u63d0\u9ad8 GABA \u53d7\u4f53\u5bf9\u620a\u5df4\u6bd4\u59a5\u7684\u654f\u611f\u6027\uff0c\u4ece\u800c\u53d1\u6325\u6539\u5584\u7761\u7720\u529f\u6548\u3002\u8fd8\u6709\u6587\u732e\u62a5\u9053\u8ba4\u4e3a GABA \u53ef\u901a\u8fc7\u80a0-\u8111\u8f74\u3001\u8111\u7ec4\u7ec7\u900f\u6027\u53ca\u5176\u4f53\u5185\u4ee3\u8c22\u7269\u591a\u9014\u5f84\u4f5c\u7528\u8fdb\u884c\u6539\u5584\u7761\u7720\u3002\u76ee\u524d GABA \u4f5c\u4e3a\u4e00\u79cd\u529f\u80fd\u6027\u6210\u5206\u4e8e 2009 \u5e74\u88ab\u536b\u751f\u90e8\u8ba4\u5b9a\u4e3a\u65b0\u98df\u54c1\u539f\u6599\uff0c\u76ee\u524d\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u98df\u54c1\u533b\u836f\u5de5\u4e1a\u3002<\/p><p><strong>5-\u7f9f\u8272\u80fa(5-hydroxytryptamine, 5-HT)<\/strong><br \/>5-HT \u662f\u5e7f\u6cdb\u5b58\u5728\u4e8e\u54fa\u4e73\u52a8\u7269\u7ec4\u7ec7\u7684\u4e00\u79cd\u6291\u5236\u6027\u795e\u7ecf\u9012\u8d28\uff0c\u4e3b\u8981\u5206\u5e03\u5728\u677e\u679c\u4f53\u548c\u4e0b\u4e18\u8111\uff0c\u53c2\u4e0e\u75db\u89c9\u3001\u7761\u7720\u548c\u4f53\u6e29\u7b49\u751f\u7406\u529f\u80fd\u8c03\u8282\u30025-HT \u4e3b\u8981\u7531\u4e2d\u7f1d\u6838\u533a\u57df\u7684\u7ec6\u80de\u4ea7\u751f\uff0c\u5176\u5728\u6162\u6ce2\u7761\u7720\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u7814\u7a76\u8868\u660e\u7535\u635f\u6bc1\u4e2d\u7f1d\u6838\u524d\u90e8\u4e4b\u540e\uff0c\u52a8\u7269\u5c06\u51fa\u73b0\u4e0d\u7720\u72b6\u6001\uff0c\u6162\u6ce2\u7761\u7720\u660e\u663e\u51cf\u5c11\uff1b\u800c\u5728\u6ce8\u5c04 5-\u7f9f\u8272\u6c28\u9178(5-Hydroxytryptophan, 5-HTP)\u540e\uff0c\u7761\u7720\u6062\u590d\u6b63\u5e38\u3002\u8272\u6c28\u9178\u4e0e 5-HTP \u5747\u4e3a 5-HT \u7684\u524d\u4f53\uff0c\u8272\u6c28\u9178\u5728\u8272\u6c28\u9178\u7f9f\u5316\u9176\u50ac\u5316\u4e0b\u9996\u5148\u751f\u6210 5-HTP\uff0c\u518d\u7ecf 5-HTP \u8131\u7fa7\u9176\u548c\u5421\u54c6\u9187\u8f85\u9176\u50ac\u5316\u751f\u6210 5-HT\uff0c\u56e0\u6b64\u901a\u8fc7\u996e\u98df\u6444\u5165\u5bcc\u542b\u8272\u6c28\u9178\u7684\u725b\u5976\u3001\u5c0f\u7c73\u7b49\u98df\u7269\u7684\u6539\u5584\u7761\u7720\u673a\u5236\u4e0e 5-HT \u6709\u5173\u3002<\/p><p>\u6587\u732e\u8868\u660e 5-HT \u65e2\u53ef\u4ee5\u4fc3\u8fdb\u89c9\u9192\uff0c\u53c8\u53ef\u4ee5\u4fc3\u8fdb\u6162\u6ce2\u7761\u7720\uff0c\u8fd9\u4e0e\u88ab\u6fc0\u6d3b\u7684 5-HT-\u53d7\u4f53\u4e9a\u578b\u6709\u5173\u3002\u8096\u97e6\u534e\u7814\u7a76\u53d1\u73b0\u67cf\u5b50\u4ec1\u6cb9\u53ef\u901a\u8fc7 5-HT\uff0c\u53bb\u7532\u80be\u4e0a\u817a\u7d20(Norepinephrine, NE)\u53ca\u591a\u5df4\u80fa(Dopamine, DA)\u4e09\u79cd\u9014\u5f84\u5171\u540c\u4f5c\u7528\u8d77\u6539\u5584\u7761\u7720\u529f\u6548\u3002\u5176\u4e2d 5-HT \u9014\u5f84\u53ef\u80fd\u662f\u901a\u8fc7\u4fc3\u8fdb\u7f1d\u9645\u6838\u4e0a\u90e8 5-HT \u7684\u91ca\u653e\u4ee5\u4fc3\u8fdb\u6162\u6ce2\u7761\u7720\u6216\u901a\u8fc7\u4fc3\u8fdb\u7f1d\u9645\u6838\u4e0b\u90e8 5-HT \u52a0\u901f\u91ca\u653e\u4f5c\u7528\u4e8e\u84dd\u6591\u4e0b\u90e8 NE \u7cfb\u7edf\u89e6\u53d1 REMS \u6765\u6539\u5584\u7761\u7720\u3002\u9ec4\u6770\u806a\u7b49\u7814\u7a76\u53d1\u73b0\u4f5b\u624b\u5b81\u795e\u65b9(\u4f5b\u624b\u3001\u767e\u5408\u3001\u9178\u67a3\u4ec1\u3001\u832f\u82d3\u3001\u83b2\u5b50)\u53ef\u901a\u8fc7\u63d0\u9ad8 5-HT \u7684\u542b\u91cf\u3001\u4e0a\u8c03 5-HT1AR \u86cb\u767d\u548c mRNA \u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u4ece\u800c\u8d77\u5230\u6539\u5584\u7761\u7720\u7684\u4f5c\u7528\u3002\u7814\u7a76\u53d1\u73b0\u9178\u67a3\u4ec1\u6c64\u53ef\u51cf\u5c11\u5927\u9f20\u81ea\u4e3b\u6d3b\u52a8\u65f6\u95f4\uff0c\u5176\u6539\u5584\u7761\u7720\u4f5c\u7528\u673a\u5236\u4e0e 5-HT1AR \u548c 5-HT2AR \u7684\u8868\u8fbe\u6709\u5173\u3002<\/p><p><strong>\u53bb\u7532\u80be\u4e0a\u817a\u7d20(Norepinephrine, NE)\u548c\u591a\u5df4\u80fa(Dopamine, DA)<\/strong><br \/>NE \u662f\u4e00\u79cd\u795e\u7ecf\u9012\u8d28\uff0c\u5bf9\u7761\u7720-\u89c9\u9192\u8fc7\u7a0b\u8d77\u8c03\u8282\u4f5c\u7528\uff0c\u5176\u91ca\u653e\u91cf\u5728\u89c9\u9192\u72b6\u6001\u8fbe\u5230\u5cf0\u503c\uff0c\u5728 NREMS \u72b6\u6001\u4e0b\u5f00\u59cb\u4e0b\u964d\uff0c\u5728 REMS \u72b6\u6001\u4e0b\u964d\u4e3a\u6700\u4f4e\u503c\u3002\u8bb8\u591a\u6cbb\u7597\u5931\u7720\u7684\u836f\u7269\u90fd\u662f\u901a\u8fc7\u6291\u5236 NE \u6765\u5f71\u54cd\u4fe1\u53f7\u4f20\u5bfc\u800c\u53d1\u6325\u4f5c\u7528\u3002NE \u4e3b\u8981\u5b58\u5728\u4e8e\u84dd\u6591\u533a\u57df\u7ec6\u80de\u4e2d\uff0c\u5728\u5feb\u6ce2\u7761\u7720\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002<\/p><p>\u82e5\u7834\u574f\u84dd\u6591\u5934\u90e8\uff0c\u8111\u7535\u663e\u793a\u7c7b\u4f3c\u7761\u7720\u7684\u540c\u6b65\u5316\u6162\u6ce2\uff1b\u7834\u574f\u84dd\u6591\u7684\u4e2d\u3001\u540e\u90e8\u795e\u7ecf\u7ec6\u80de\uff0c\u5219\u5feb\u6ce2\u7761\u7720\u6d88\u5931\u3002DA \u4e3a\u4f53\u5185\u5408\u6210 NE \u7684\u524d\u4f53\u7269\uff0c\u4e00\u822c\u8ba4\u4e3a DA \u795e\u7ecf\u5143\u5174\u594b\uff0c\u89c9\u9192\u589e\u52a0\uff0c\u52a8\u7269\u7761\u7720\u51cf\u5c11\uff1b\u53cd\u4e4b\u7761\u7720\u65f6\u95f4\u589e\u957f\u3002DA \u9014\u5f84\u662f\u901a\u8fc7\u8c03\u8282\u4e2d\u8111 DA \u542b\u91cf\uff0c\u6291\u5236\u8111\u5185 DA \u795e\u7ecf\u5143\u6d3b\u52a8\uff0c\u4ece\u800c\u6539\u5584\u5c0f\u9f20\u7761\u7720\u8d28\u91cf\u3002\u8096\u97e6\u534e\u7814\u7a76\u53d1\u73b0\u67cf\u5b50\u4ec1\u6cb9\u7684 NE \u9014\u5f84\u662f\u901a\u8fc7\u4fc3\u8fdb\u84dd\u6591\u4e2d\u3001\u4e0b\u90e8 NE \u7684\u91ca\u653e\uff0c\u4ece\u800c\u4fc3\u8fdb REMS\uff1b\u5eb7\u7490\u7b49\u7814\u7a76\u53d1\u73b0\u6800\u5b50\u8c49\u6c64\u548c\u5929\u738b\u8865\u5fc3\u4e39\u53ef\u901a\u8fc7\u8c03\u8282 NE \u53ca 5-HT \u542b\u91cf\u4ece\u800c\u8fbe\u5230\u6539\u5584\u5c0f\u9f20\u7761\u7720\u7684\u4f5c\u7528\u3002<\/p><p><strong>\u8c37\u6c28\u9178(glutamic acid, Glu)<\/strong><br \/>Glu \u662f\u4e00\u79cd\u8111\u5185\u542b\u91cf\u6700\u591a\u7684\u5174\u594b\u6027\u795e\u7ecf\u9012\u8d28\uff0c\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u8c03\u8282\u4f5c\u7528\u3002\u5f53\u795e\u7ecf\u51b2\u52a8\u4f20\u81f3\u795e\u7ecf\u672b\u68a2\u65f6\uff0c\u7a81\u89e6\u524d\u819c\u91ca\u653e Glu\uff0c\u5e76\u8fc5\u901f\u6269\u6563\u5230\u7a81\u89e6\uff0c\u4e0e\u53d7\u4f53\u7ed3\u5408\uff0c\u4fc3\u4f7f Na+\u548c K+\u901a\u9053\u95e8\u5f00\u653e\uff0c\u4ece\u800c\u4ea7\u751f\u5174\u594b\u6548\u5e94\u3002\u6587\u732e\u8ba4\u4e3a Glu \u4e0e N-\u7532\u57fa-D-\u5929\u51ac\u6c28\u9178\u53d7\u4f53(NMDA \u53d7\u4f53)\u4eb2\u548c\u529b\u8f83\u9ad8\uff0c\u53ef\u5f15\u8d77 NMDA \u53d7\u4f53\u901a\u9053\u53cd\u590d\u5f00\u653e\uff0c\u9020\u6210 Ca2+\u5185\u6d41\u4ee5\u53ca Glu \u53d7\u4f53\u6fc0\u6d3b\u5f15\u8d77\u7ec6\u80de\u5185 Ca2+\u91ca\u653e\uff0c\u4f7f\u7ec6\u80de\u5185 Ca2+\u6d53\u5ea6\u6301\u7eed\u589e\u9ad8\uff0c\u4ece\u800c\u5f15\u53d1\u7761\u7720\u969c\u788d\u3002\u675c\u6668\u6656\u7b49\u7814\u7a76\u53d1\u73b0\u9178\u67a3\u4ec1\u53ef\u663e\u8457\u964d\u4f4e\u5927\u9f20 Glu \u542b\u91cf\uff0c\u53ef\u63a8\u6d4b\u5176\u529f\u80fd\u673a\u5236\u4e0e\u8c03\u8282 Glu \u542b\u91cf\u6709\u5173\u3002<\/p><p>\u6b64\u5916\uff0c\u5f20\u821c\u6ce2\u7b49\u7814\u7a76\u53d1\u73b0\u9178\u67a3\u4ec1\u603b\u7682\u82f7\u53ef\u901a\u8fc7\u4e0b\u8c03\u5927\u9f20 Glu \u548c GABA \u4e24\u79cd\u795e\u7ecf\u9012\u8d28\u7684\u542b\u91cf\u53ca\u6bd4\u503c\u6765\u51cf\u8f7b\u8111\u5185\u5174\u594b\u6027\u795e\u7ecf\u6bd2\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6539\u5584\u7761\u7720\u7684\u529f\u6548\uff0c\u8bf4\u660e\u9178\u67a3\u4ec1\u53ef\u901a\u8fc7 Glu \u4e0e GABA \u673a\u5236\u8d77\u5230\u9547\u9759\u50ac\u7720\u7684\u4f5c\u7528\u3002GABA \u5c5e\u5f3a\u795e\u7ecf\u6291\u5236\u6027\u6c28\u57fa\u9178\uff0c\u800c Glu \u5c5e\u5174\u594b\u6027\u795e\u7ecf\u9012\u8d28\uff0c\u56e0\u6b64\u8bb8\u591a\u6539\u5584\u7761\u7720\u8d44\u6e90\u90fd\u662f\u901a\u8fc7\u6539\u5584 Glu\/GABA \u7684\u5174\u594b\/\u6291\u5236\u4ee3\u8c22\u5931\u8861\u3001\u8c03\u8282 Glu\/GABA \u7684\u6bd4\u503c\u6765\u53d1\u6325\u4f5c\u7528\u3002<\/p><p><strong>\u892a\u9ed1\u7d20\uff08melatonin\uff09<\/strong><br \/>\u892a\u9ed1\u7d20\u662f\u7531\u54fa\u4e73\u52a8\u7269\u548c\u4eba\u7c7b\u7684\u677e\u679c\u4f53\u4ea7\u751f\u7684\u4e00\u79cd\u80fa\u7c7b\u6fc0\u7d20\uff0c\u53ef\u7f29\u77ed\u89c9\u9192\u65f6\u95f4\u548c\u5165\u7761\u65f6\u95f4\u3002\u892a\u9ed1\u7d20\u662f\u901a\u8fc7\u6fc0\u6d3b MT1\u548c MT2 \u00a0\u00a0\u53d7\u4f53\u8fdb\u884c\u8c03\u8282\u7761\u7720\u3002MT1 \u4e3b\u8981\u6291\u5236\u795e\u7ecf\u5143\u6d3b\u52a8\uff0c\u8c03\u8282\u7761\u7720\uff1bMT2 \u4e3b\u8981\u6d89\u53ca\u663c\u591c\u8282\u5f8b\u3002Rodriguez-Naranjo \u7b49\u53d1\u73b0\u8461\u8404\u9152\u5728\u53d1\u9175\u8fc7\u7a0b\u4e2d\u4f1a\u5f62\u6210\u892a\u9ed1\u7d20\uff0c\u6545\u98df\u7528\u8461\u8404\u9152\u6709\u52a9\u4e8e\u6539\u5584\u7761\u7720\u3002\u6838\u6843\u5bcc\u542b\u8272\u6c28\u9178\u4e0e\u892a\u9ed1\u7d20\uff0c\u800c\u98df\u6e90\u6027\u8272\u6c28\u9178\u5728\u4f53\u5185\u53ef\u6700\u7ec8\u8f6c\u5316\u4e3a\u892a\u9ed1\u7d20\uff0c\u6838\u6843\u6539\u5584\u7761\u7720\u4e0e\u892a\u9ed1\u7d20\u673a\u5236\u76f8\u5173\u3002\u76ee\u524d\u56fd\u5185\u5916\u5bf9\u892a\u9ed1\u7d20\u7684\u751f\u7406\u529f\u80fd\uff0c\u5c24\u5176\u662f\u4f5c\u4e3a\u81b3\u98df\u8865\u5145\u5242\u7684\u4fdd\u5065\u529f\u80fd\u8fdb\u884c\u4e86\u5e7f\u6cdb\u7814\u7a76\uff0c\u8868\u660e\u5176\u5177\u6709\u6539\u5584\u7761\u7720\u3001\u8c03\u8282\u65f6\u5dee\u3001\u6297\u8870\u8001\u3001\u514d\u75ab\u8c03\u8282\u3001\u6297\u80bf\u7624\u7b49\u591a\u65b9\u9762\u751f\u7406\u529f\u80fd\u3002<\/p><p><strong>\u5176\u4ed6\u795e\u7ecf\u9012\u8d28<\/strong><br \/>\u4e00\u6c27\u5316\u6c2e(Nitric Oxide, NO)\u3001\u4e59\u9170\u80c6\u78b1(acetylcholine, Ach)\u548c\u7ec4\u80fa\u7b49\u795e\u7ecf\u9012\u8d28\u4e5f\u80fd\u53c2\u4e0e\u7761\u7720-\u89c9\u9192\u5468\u671f\u7684\u8c03\u8282\uff0c\u8c03\u8282\u5176\u542b\u91cf\u53ef\u8fbe\u5230\u6539\u5584\u7761\u7720\u7684\u4f5c\u7528\u3002\u9ec4\u8389\u8389\u7b49\u7814\u7a76\u53d1\u73b0\u56db\u9006\u6563\u53ef\u663e\u8457\u589e\u52a0\u5c0f\u9f20\u5168\u8111\u7684 NO \u00a0\u542b\u91cf\u548c\u4e00\u6c27\u5316\u6c2e\u5408\u9176(NOS)\u7684\u6d3b\u6027\uff1b\u9002\u91cf\u589e\u52a0\u5185\u6e90\u6027 NO \u542b\u91cf\u53ef\u5ef6\u957f\u5c0f\u9f20\u7761\u7720\u65f6\u95f4\u3001\u7f29\u77ed\u7761\u7720\u6f5c\u4f0f\u671f\uff0c\u8bf4\u660e\u56db\u9006\u6563\u53ef\u901a\u8fc7\u9002\u91cf\u589e\u52a0 NO \u542b\u91cf\u3001\u589e\u5f3a NOS \u6d3b\u529b\u6765\u53d1\u6325\u6539\u5584\u7761\u7720\u529f\u80fd\u3002\u5b59\u6613\u5a1c\u7b49\u7814\u7a76\u53d1\u73b0\u4eba\u53c2\u3001\u77f3\u83d6\u84b2\u4ee5\u53ca\u4eba\u53c2-\u77f3\u83d6\u84b2\u836f\u5bf9\u53ef\u5ef6\u957f\u5c0f\u9f20\u7761\u7720\u65f6\u95f4\u3001\u7f29\u77ed\u5c0f\u9f20\u7761\u7720\u6f5c\u4f0f\u671f\uff0c\u4e14\u4e2d\u836f\u5e72\u9884\u7ec4\u4e0e\u7761\u7720\u5265\u593a\u7ec4\u5927\u9f20\u8111\u7ec4\u7ec7\u4e2d\u7684 Ach \u542b\u91cf\u3001\u4e59\u9170\u80c6\u78b1\u8f6c\u79fb\u9176(ChAT)\u6d3b\u6027\u5b58\u5728\u663e\u8457\u6027\u5dee\u5f02\uff0c\u8bf4\u660e\u4eba\u53c2-\u77f3\u83d6\u84b2\u5b89\u795e\u7684\u529f\u6548\u4e0e\u8c03\u8282 Ach \u542b\u91cf\u6709\u5173\u3002<\/p><p><strong>\u2022 \u514d\u75ab\u8c03\u8282\u4f5c\u7528<\/strong><br \/>\u5f53\u7ec6\u83cc\u548c\u75c5\u6bd2\u611f\u67d3\u540e\u53ef\u6fc0\u6d3b\u673a\u4f53\u514d\u75ab\u529f\u80fd\uff0c\u540c\u65f6\u4e5f\u80fd\u4fc3\u8fdb\u7761\u7720\uff0c\u5176\u514d\u75ab\u8c03\u8282\u7269\u8d28\u53ef\u80fd\u4f5c\u7528\u4e8e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4ece\u800c\u5f71\u54cd\u7761\u7720\u8fc7\u7a0b\uff0c\u8bb8\u591a\u514d\u75ab\u589e\u5f3a\u5242\u4e5f\u53ef\u4ee5\u589e\u52a0\u7761\u7720\u3002<\/p><p>Imeri\u7b49\u7684\u7814\u7a76\u8868\u660e\uff0c\u767d\u7ec6\u80de\u4ecb\u7d201(IL-1)\u53ef\u80fd\u4e0e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u4fc3\u8fdb\u6b63\u5e38\u7761\u7720\u7684\u8c03\u8282\u3002\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(TNF)\u4e5f\u662f\u514d\u75ab\u7cfb\u7edf\u91cd\u8981\u7684\u7ec6\u80de\u56e0\u5b50\u4e4b\u4e00\uff0c\u53ef\u53c2\u4e0eNREMS\u7684\u8c03\u8282\uff0c\u901a\u8fc7\u589e\u5f3a5-HT\u7cfb\u7edf\u7684\u529f\u80fd\u4ece\u800c\u8fbe\u5230\u4fc3\u8fdb\u7761\u7720\u7684\u4f5c\u7528\u3002\u738b\u4e07\u91cc\u7814\u7a76\u53d1\u73b0\u4eba\u53c2\u7682\u82f7Rb1\u53ef\u901a\u8fc7\u8c03\u8282\u5927\u9f20\u6d77\u9a6c\u3001\u4e0b\u4e18\u8111IL-1\u03b2\u548cTNF-\u03b1\u7684\u8868\u8fbe\u4ece\u800c\u6539\u53d8\u7761\u7720\u7ed3\u6784\uff0c\u8bf4\u660e\u4eba\u53c2\u7682\u82f7Rb1\u6539\u53d8\u7761\u7720\u53ef\u80fd\u4e0e\u8c03\u8282\u514d\u75ab\u7ec6\u80de\u56e0\u5b50\u6709\u5173\u3002<\/p><p><strong>\u2022 \u80a0\u9053\u83cc\u7fa4\u8c03\u8282\u4f5c\u7528<\/strong><br \/>\u80a0\u9053\u83cc\u7fa4\u662f\u4eba\u4f53\u80c3\u80a0\u9053\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u4e5f\u662f\u8111\u80a0\u8f74\u7684\u4e3b\u8981\u53c2\u4e0e\u8005\u3002Reynolds\u7b49\u8ba4\u4e3a\u7761\u7720\u4e0e\u80a0\u9053\u83cc\u7fa4\u6709\u7740\u5bc6\u5207\u7684\u5173\u7cfb\uff0c\u77ed\u65f6\u95f4\u7761\u7720\u4f1a\u5f15\u53d1\u751f\u7406\u5e94\u6fc0\u53cd\u5e94\uff0c\u800c\u751f\u7406\u548c\u5fc3\u7406\u5e94\u6fc0\u90fd\u4f1a\u7834\u574f\u80a0\u9053\u83cc\u7fa4\u7684\u6b63\u5e38\u529f\u80fd\u3002\u80a0\u9053\u83cc\u7fa4\u5219\u901a\u8fc7\u795e\u7ecf\u3001\u514d\u75ab\u548c\u5185\u5206\u6ccc\u9014\u5f84\u4e0e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8fdb\u884c\u6c9f\u901a\u4ea4\u6d41\uff0c\u4ece\u800c\u5f71\u54cd\u5927\u8111\u7684\u529f\u80fd\u4e0e\u884c\u4e3a\u3002Jackson\u7b49\u7814\u7a76\u53d1\u73b0\u6539\u5584\u80a0\u9053\u5fae\u751f\u7269\u5206\u5e03\u53ef\u6709\u6548\u6539\u5584\u7761\u7720\u548c\u60c5\u7eea\u3002\u9648\u633a\u5f3a\u7814\u7a76\u53d1\u73b0\u9999\u8549\u4f4e\u805a\u7cd6\u53ef\u8c03\u6574\u80a0\u9053\u5fae\u751f\u7269\u83cc\u843d\u7ec4\u6210\u7ed3\u6784\uff0c\u9999\u8549\u6539\u5584\u7761\u7720\u529f\u80fd\u53ef\u80fd\u4e0e\u5176\u6539\u5584\u80a0\u9053\u83cc\u7fa4\u6709\u5173\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2694150 elementor-widget elementor-widget-text-editor\" data-id=\"2694150\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>03.\u6539\u5584\u7761\u7720\u4fdd\u5065\u98df\u54c1\u53ca\u8d44\u6e90\u5e94\u7528<\/p><div>\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fcd1e68 elementor-widget elementor-widget-text-editor\" data-id=\"fcd1e68\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div 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